What is Chapter 05 of ICD-11?
The Chapter 05 group the endocrine, nutritional or metabolic diseases. It is one of the chapters with the greatest global clinical relevance given that it includes diabetes mellitus, thyroid disorders, obesity and metabolic disorders — conditions of very high prevalence throughout the world.
In the ICD-10, this content corresponded to Chapter IV (E00–E90). ICD-11 reorganizes it into four main sections:
- Endocrine diseases — organized by gland or hormonal system
- Nutritional disorders — malnutrition, vitamin and mineral deficiencies, obesity
- Metabolic disorders — now classified by etiology: inborn errors, absorption/transport, electrolyte balance
- Endocrine or metabolic disorders after the procedure
Section 1 — Endocrine Diseases
Organized by specific gland or hormonal system. Includes thyroid, pancreas, pituitary, adrenals, parathyroid and gonads.
Includes hypothyroidism, thyrotoxicosis (hyperthyroidism), thyroiditis and other thyroid disorders. The structure did not change from ICD-10, but the terminology was revised to better reflect current disease processes.
| Code | Diagnosis |
|---|---|
| 5A00 | Hypothyroidism |
| 5A00.0 | Congenital hypothyroidism |
| 5A00.1 | Iodine-deficiency-related thyroid disorders or allied conditions |
| 5A01 | Nontoxic goitre |
| 5A02 | Thyrotoxicosis |
| 5A03 | Thyroiditis |
| 5A0Z | Disorders of the thyroid gland or thyroid hormones system, unspecified |
The most consulted block of the chapter. The ICD-11 expands the types of diabetes and adds intermediate hyperglycemia (prediabetes) as its own entity. Diabetic complications are coded in the affected system chapter, linked to the type of diabetes using the "Code also" instruction.
| Code | Diagnosis |
|---|---|
| 5A10 | Type 1 diabetes mellitus |
| 5A11 | Type 2 diabetes mellitus |
| 5A12 | Malnutrition-related diabetes mellitus |
| 5A13 | Diabetes mellitus, other specified type |
| 5A14 | Diabetes mellitus, type unspecified |
| 5A40.Z | Intermediate hyperglycaemia, unspecified |
| 5A21 | Hypoglycaemia in the context of diabetes mellitus |
| 5A22 | Diabetic acidosis |
| 5A23 | Diabetic coma |
| 5A41 | Hypoglycaemia without associated diabetes |
Disorders of the endocrine pancreas other than diabetes mellitus. Without structural changes with respect to ICD-10.
| Code | Diagnosis |
|---|---|
| 5A40 | Intermediate hyperglycaemia |
| 5A41 | Hypoglycaemia without associated diabetes |
| 5A4Z | Disorders of glucose regulation or pancreatic internal secretion, unspecified |
ICD-11 disaggregates the E20–E35 block of ICD-10 into more specific sections: parathyroid, pituitary, adrenal, gonads, puberty, and polyglandular. Each section follows the affected gland or hormonal system.
| Code | Diagnosis |
|---|---|
| 5A50 | Hypoparathyroidism |
| 5A51 | Hyperparathyroidism |
| 5A60 | Hyperfunction of pituitary gland |
| 5A60.0 | Acromegaly or pituitary gigantism |
| 5A61.0 | Hypopituitarism |
| 5A70 | Cushing syndrome |
| 5A74.Z | Adrenocortical insufficiency, unspecified |
| 5A71.0 | 46,XX disorders of sex development induced by androgens of fetal origin |
| 5A72.Z | Hyperaldosteronism, unspecified |
| 5A80 | Ovarian dysfunction |
| 5A81 | Testicular dysfunction or testosterone-related disorders |
| 5A90 | Disorder of puberty due to oestrogen resistance |
| 5A91 | Delayed puberty |
Section 2 — Nutritional Disorders
The ICD-11 incorporates updated terminology and a more detailed classification for vitamin and mineral deficiencies, as well as obesity.
ICD-11 adds two new subsections: malnutrition based on anthropometric or clinical criteria, and malnutrition due to specific nutritional deficiencies. Relevant for pediatrics and intensive care medicine.
| Code | Diagnosis |
|---|---|
| 5B50 | Underweight in infants, children or adolescents |
| 5B51 | Wasting in infants, children or adolescents |
| 5B52 | Acute malnutrition in infants, children or adolescents |
| 5B53 | Stunting in infants, children or adolescents |
| 5B55.Z | Vitamin A deficiency, unspecified |
| 5B57.0 | Vitamin D deficiency rickets |
| 5B56.Z | Vitamin C deficiency, unspecified |
| 5B71 | Protein deficiency |
| 5B7Z | Unspecified undernutrition |
One of the most frequently coded blocks in primary care and internal medicine. The ICD-11 offers greater specificity for types of obesity in adults, children and adolescents.
| Code | Diagnosis |
|---|---|
| 5B80.01 | Overweight in adults |
| 5B81.01 | Obesity in adults |
| 5B81.0 | Obesity due to energy imbalance |
| 5B81.1 | Drug-induced obesity |
Section 3 — Metabolic Disorders
ICD-11 classifies metabolic disorders by etiology, in three broad areas, unlike the ICD-10 which used a less systematic organization.
Dyslipidemia and cholesterol and triglyceride disorders. One of the most codified blocks in cardiology and preventive medicine.
| Code | Diagnosis |
|---|---|
| 5C80 | Hyperlipoproteinaemia |
| 5C80.00 | Primary hypercholesterolaemia |
| 5C80.1 | Hypertriglyceridaemia |
| 5C80.2 | Mixed hyperlipidaemia |
| 5C80.3 | Hyperalphalipoproteinaemia |
| 5C81 | Hypolipoproteinaemia |
| 5C8Z | Unspecified disorders of lipoprotein metabolism or lipidaemias |
New etiological approach in ICD-11. It includes inborn errors of metabolism (hereditary metabolic diseases), disorders of absorption and transport of metabolites, and disorders of water-electrolyte balance.
| Code | Diagnosis |
|---|---|
| 5C50 | Inborn errors of amino acid or other organic acid metabolism |
| 5C50.0 | Phenylketonuria |
| 5C51 | Inborn errors of carbohydrate metabolism |
| 5C51.0 | Disorders of the pentose phosphate pathway |
| 5C55 | Inborn errors of purine, pyrimidine or nucleotide metabolism |
| FA25 | Gout |
| 5C58.1Z | Porphyrias, unspecified |
| 5C70 | Volume depletion |
| 5C73 | Acidosis |
| 5C76 | Hyperkalaemia |
| 5C77 | Hypokalaemia |
Endocrine or metabolic disorders that occur as a consequence of medical or surgical intervention. These codes should not be used as the underlying cause of death.
| Code | Diagnosis |
|---|---|
| 5D40 | Postprocedural hypothyroidism |
| 5D41 | Postprocedural hypoinsulinaemia |
| 5D44 | Postprocedural ovarian failure |
| 5D46 | Postprocedural adrenocortical hypofunction |
Comparison ICD-10 vs ICD-11 — Chapter 05
| ICD-10 block | ICD-11 Equivalent |
|---|---|
| E00–E07 Thyroid gland disorders | 5A00–5A0Z Thyroid disorders (revised structure, updated terminology) |
| E10 Type 1 diabetes | 5A10 Diabetes mellitus type 1 |
| E11 Type 2 diabetes | 5A11 Diabetes mellitus type 2 |
| E13 Other specified diabetes | 5A13 Diabetes mellitus, other type (includes MODY and others) |
| E14 Unspecified diabetes mellitus | 5A14 Diabetes mellitus, unspecified type |
| It did not exist as an independent entity | 5A20 Intermediate hyperglycemia (prediabetes) — new in ICD-11 |
| E15–E16 Other disorders of the endocrine pancreas | 5A40–5A4Z No structural changes |
| E20–E35 Disorders of other endocrine glands | 5A50–5A9Z Disaggregated by gland: parathyroid, pituitary, adrenal, gonads, puberty |
| E40–E46 Malnutrition | 5B50–5B7Z Malnutrition (with new anthropometric subsections) |
| E50–E64 Other nutritional deficiencies | 5B60–5B7Z Part of malnutrition cluster |
| E65–E68 Obesity and other types of hypernutrition | 5B80–5B8Z Overweight, obesity or nutrient excess |
| E70–E90 Metabolic disorders | 5C50–5D3Z Metabolic disorders with subsections by etiology |
| E89 Postprocedure endocrine and metabolic disorders | 5D40–5D46 Endocrine or metabolic disorders following the procedure |